Scientists Write Guide for Creating Mouse-Human Embryos

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Scientists Write Guide for Creating Mouse-Human Embryos Last year, scientists at the University of Buffalo demonstrated a process able to produce mature human cells in a mouse embryo. They have now documented the process for creating chimeric mouse-human embryos and published a detailed description allowing other labs to replicate the process. This ability to produce mature human cells in a living organism is invaluable to research in the use of stem cells to treat disease in humans. These mature cells are produced by converting the stem cells into a less developed state in order for the cells to co-develop. This has been done before, but now the procedure has been published in Nature Protocols after the significant interest generated by the project led to an invitation to publish. The research will allow more scientists to use this technology as a platform for studying human diseases. As the research develops, it will help us move toward a better human model system to study any condition. It will spur more discoveries and applications that could lead to a new understanding of human biology and medicine. The researchers add that a better understanding of how human cells develop in chimera may enable the generation of human cells in artificial systems and fundamentally change how diseases are treated. Supporters of the work included NYSTEM and the Buffalo Blue Sky Initiative.

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